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Item Number: 2576

Selenium Phosphate pack of 90 capsules *

£22.51 Exc. VAT

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P U R E  •  T R U S T E D  •  V E G A N

+ Purest Formulas
Here at Epigenetics, the quality and purity of each ingredient is integral to our development of effective, bioavailable formulas. Our products are naturally pesticide-free and completely free from artificial fillers, additives, lubricants, binders, bulking agents and preservatives.

+ Trusted Quality
Proudly made in our UK based production facility, set in the heart of the countryside. Your trust in us matters, and as such, we adhere to the strictest GMP regulations and guidelines when producing all of our products.

+ Vegan Friendly
We respect nature and as such we do our part and only use vegan-friendly ingredients in our Selenium Phosphate.

+ Letterbox Friendly
Our capsules come in small postal packs, designed for easy, contact-free delivery. The smaller design leads to a reduced carbon footprint during the shipping process.

+ FDA Compliant 
* – An FDA compliant product – can be shipped to the USA

This product has been updated:
+ Reduced from 120 capsules to 90
+ Price reduced to £22.51 excluding VAT
+ Capsule size increased
+ Microcrystalline Cellulose (natural filler) added


Selenium Phosphate

Selenium is an essential trace mineral that plays an important role in human health. It is naturally present in foods such as Brazil nuts, seafood, eggs, meat, and whole grains but it can also be obtained through dietary supplements (1).

Selenium is a critical component in more than 24 selenoproteins that are necessary for the production of essential hormones, DNA synthesis, and protection from oxidative damage (2). The most important of these are glutathione peroxidase and thioredoxin reductase (3). These selenoproteins help prevent damage to cells by acting as antioxidants, neutralising free radicals and reactive oxygen species (4). Selenium plays an important role in immune function by helping white blood cells recognise infection-causing bacteria and viruses (5). Likewise, it is needed for thyroid hormone metabolism and may also help prevent cancer (5).

Dietary selenium is absorbed in the gastrointestinal tract, metabolised by the liver, and used for producing selenoproteins. It is then transported to other tissues of the body (6). Most is stored in muscle tissue although due to various selenoproteins that assist with thyroid function, a huge proportion is held in the thyroid gland (1).

Selenium deficiency can lead to numerous health problems, including hair loss, slow growth in children, muscle weakness, irritability, fatigue and infertility in men and women (7). Severe selenium deficiency has been associated with Keshan disease, a dilated cardiomyopathy and Kashin-Beck disease, a form of osteoarthritis (1). Additionally, when combined with iodine deficiency can lead to myxedematous cretinism, a severe form of dwarfism (8).

In the UK, the recommended nutrient intake (RNI) for selenium is 75 micrograms/day for men and 60 micrograms/day for women. While the levels vary depending on age, the British Nutrition Foundation suggestions can be found in table 1 (9).

Table 1. Recommended Nutrient Intakes for Selenium (9)

Age Male Female Pregnancy Lactation
1-3 years 15µg/d 15µg/d
4-6 years 20µg/d 20µg/d
7-10 years 30µg/d 30µg/d
11-14 years 45µg/d 45µg/d
15-18 years 70µg/d 60µg/d
19-50 years 75µg/d 60µg/d 75µg/d
50+ years 75µg/d 60µg/d

If pregnant or breast-feeding, have skin cancer, hypothyroidism, autoimmune disease or have chronic kidney disease (and are on haemodialysis), please consult your health care practitioner before using this product as dosage may vary or be dangerous (10). Selenium can also interact with certain medications such as Cisplatin so if on medication, consult your doctor before use (2).

Selenium toxicity can occur when you take too much selenium through supplements or food. Selenium toxicity symptoms include metallic taste in mouth, nausea, hair loss and muscle tenderness however more severe problems can occur if in excess over a long period of time (1).

Epigenetics Selenium Phosphate is produced in a convenient, vegan friendly capsule. Recommended daily dose is 1 serving per day taken with a meal, or as directed by a healthcare practitioner. This product is not intended to be used as an alternative to a varied diet.

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Selenium is an essential trace mineral with a number of important functions in the human body. Over two dozen selenoproteins reply on selenium for their production and these play an important role in many biological processes in the body (11). Selenium can be organic (Selenite and selenate) and inorganic (selenomethionine and selenocysteine) and both are beneficial and can be found in dietary sources (2).

Selenium is found in Brazil nuts, beans, beef, chicken, turkey, and seafood. However, the amount of selenium in these foods vary depending upon the levels present in soil where those foods are grown. Plants absorb selenium from soil and produce plant sources of the element; animals eat these plants, producing the animal sources (1).

One of the main advantages of selenium is its antioxidant properties. It is an extremely powerful antioxidant helping to protect against oxidative damage. Likewise, it is a cofactor to many enzymes. Enzymes such as glutathione peroxidase, thioredoxin reductase and iodothyronine deiodinases all rely on selenium to function (12). Glutathione is especially important in the detoxification of the liver, oxidative stress reduction and reducing free radicals (13). Furthermore, due to its high antioxidant effects and its ability to reduce DNA damage in the mitochondria and nucleus of the cell, selenium may help to reduce the risk of certain cancers (14, 15). However, further research is needed to determine if there is a direct link between selenium and cancer.

In addition to its antioxidant properties, selenium helps protects the thyroid gland from oxidative stress (16). The thyroid gland contains the highest concentration of selenium in the body (2) and is required for the conversion of T4 to T3 (16). This is particularly important in those suffering from Hashimoto’s disease. This suggests that selenium may be crucial in certain autoimmune diseases as it can significantly reduce thyroid peroxidase antibodies as well as hydrogen peroxide which generates free radicals (17). Likewise, a selenium deficiency may result in further thyroid problems such as thyroiditis, hypothyroidism, and Graves’ disease (17).

The antioxidant activity of selenium may help reduce the risk of cognitive decline and other age-related cognitive impairments (14). It has been suggested that selenium and its compounds can be used to prevent or treat Alzheimer’s disease (18). Further evidence has shown that adults with Alzheimer’s had notably lower selenium levels compared to those without the disease (19). This highlights the importance of selenium in preventing oxidative stress which ultimately can lead to neurological impairment. However, a lot more research is needed on this before specific recommendations can be made.

Moreover, selenium supplementation has the ability to help detoxify mercury (20), help improve the glycaemic and lipidemic profile of type 2 diabetics (21) and potentially help reduce the risk of cardiovascular diseases (1).

Nausea, vomiting, seizures and mental confusion are all symptoms of selenium deficiency (1). Moderate deficiency leads to infertility in men and prostate cancer, as well as neurological diseases. Severe selenium deficiency can lead to heart muscle and joint problems (22) and has been associated with Keshan disease and Kashin-Beck disease (1).

Those most at risk of selenium deficiency are people with HIV because diarrhoea and other symptoms can reduce absorption rates (1). People undergoing dialysis may also be at risk due to selenium lost when filtering the blood and strict food intake requirements (1).  Individuals suffering from Chron’s disease or colitis might have lower levels due to malabsorption. Similarly, as selenium is metabolised by the liver, those with cirrhosis of the liver may be at risk of deficiency (23). People living in regions that have a low selenium soil content can also be at risk (1).

While it is rare, it is important to note that excess selenium can be toxic and even fatal. Early symptoms of selenium toxicity include a garlic-like odour in the breath and a metallic taste in the mouth (2). Other symptoms include nausea, vomiting, nail discoloration, brittleness, hair loss, fatigue, and irritability (24). In extreme cases, long term selenium toxicity can result in kidney failure, cardiac failure or even death (2). It is therefore key that Epigenetics Selenium Phosphate supplements be taken with care.


Ingredient Amount per serving ECRDA* %DV*
Adenosine triphosphate 60 mg
Selenium (from Sodium selenate) 100 µg 182%* 143%*

* Percent Daily Reference Intakes (RI) are based on a 2,000 calorie diet.

† Percent Daily Reference Intakes (RI) not established.

INGREDIENTS: Microcrystalline cellulose, Adenosine triphosphate, Vegetable capsule (Hydroxypropyl methylcellulose), Silicon dioxide, Sodium selenate.

Suitable for vegans

Product Information

Packaging: 90 capsules

Recommended daily dose, 1 serving taken with a meal.

Serving size: 1 capsule, Servings per container: 90

Store in a cool dry place out of reach and sight of children. Once opened, consume within 9 months.



  1. Selenium (2021) The Nutrition Source. Available at: (Accessed: January 10, 2023).
  2. Office of dietary supplements – selenium (2023) NIH Office of Dietary Supplements. U.S. Department of Health and Human Services. Available at: (Accessed: January 10, 2023).
  3. Andrade, I.G. et al. (2021) “Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: Association with oxidative stress and lipid status biomarkers,” Orphanet Journal of Rare Diseases, 16(1). Available at:
  4. Madeja, Z. et al. (2005) “The role of thioredoxin reductase activity in selenium-induced cytotoxicity,” Biochemical Pharmacology, 69(12), pp. 1765–1772. Available at:
  5. Huang, Z., Rose, A. H., & Hoffmann, P. R. (2012). The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxidants & redox signaling16(7), 705–743. Available at:
  6. Ferreira, R.L. et al. (2021) “Selenium in human health and gut microflora: Bioavailability of selenocompounds and relationship with diseases,” Frontiers in Nutrition, 8. Available at:
  7. Selenium deficiency, Healthline (2018). Healthline Media. Available at: (Accessed: January 10, 2023).
  8. Zimmermann, M.B. and Köhrle, J. (2004) “The impact of iron and selenium deficiencies on iodine and thyroid metabolism: Biochemistry and relevance to Public Health,” Thyroid, 12(10), pp. 867–878. Available at:
  9. – British Nutrition Foundation (2023). Available at: (Accessed: January 10, 2023).
  10. Selenium: Overview, uses, side effects, precautions, interactions, dosing and reviews (2023) WebMD. WebMD. Available at:,weeks%20before%20a%20scheduled%20surgery. (Accessed: January 10, 2023).
  11. Wang, Z., Kong, L., Zhu, L., Hu, X., Su, P., & Song, Z. (2021). The mixed application of organic and inorganic selenium shows better effects on incubation and progeny parameters. Poultry science100(2), 1132–1141.
  12. Tinggi U. (2008). Selenium: its role as antioxidant in human health. Environmental health and preventive medicine13(2), 102–108.
  13. Kaplowitz N. (1981). The importance and regulation of hepatic glutathione. The Yale journal of biology and medicine54(6), 497–502
  14. 7 science-based health benefits of selenium, Healthline. Healthline Media. Available at: (Accessed: January 11, 2023).
  15. Rayman M. P. (2005). Selenium in cancer prevention: a review of the evidence and mechanism of action. The Proceedings of the Nutrition Society64(4), 527–542.
  16. Ventura, M., Melo, M., & Carrilho, F. (2017). Selenium and Thyroid Disease: From Pathophysiology to Treatment. International journal of endocrinology2017, 1297658.
  17. Santos LR, Neves C, Melo M, Soares P. Selenium and Selenoproteins in Immune Mediated Thyroid Disorders. Diagnostics. 2018; 8(4):70.
  18. Zhang, Z.-H. and Song, G.-L. (2021) “Roles of selenoproteins in brain function and the potential mechanism of selenium in alzheimer’s disease,” Frontiers in Neuroscience, 15. Available at:
  19. Varikasuvu, S. R., Prasad V, S., Kothapalli, J., & Manne, M. (2019). Brain Selenium in Alzheimer’s Disease (BRAIN SEAD Study): a Systematic Review and Meta-Analysis. Biological trace element research189(2), 361–369.
  20. Spiller H. A. (2018). Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity. Clinical toxicology (Philadelphia, Pa.)56(5), 313–326.
  21. Karalis D. T. (2019). The Beneficiary Role of Selenium in Type II Diabetes: A Longitudinal Study. Cureus11(12), e6443.
  22. Rayman M. P. (2012). Selenium and human health. Lancet (London, England)379(9822), 1256–1268.
  23. Selenium deficiency symptoms, causes and treatments, Axe. (2022) Available at: (Accessed: January 11, 2023).
  24. MacFarquhar, J. K., Broussard, D. L., Melstrom, P., Hutchinson, R., Wolkin, A., Martin, C., Burk, R. F., Dunn, J. R., Green, A. L., Hammond, R., Schaffner, W., & Jones, T. F. (2010). Acute selenium toxicity associated with a dietary supplement. Archives of internal medicine170(3), 256–261.


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